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General

Autoimmune conditions that coexist with endometriosis: when to test?

The short answer

Persistent fatigue out of proportion to sleep, heat or cold intolerance, chronic diarrhea, joint pain with swelling or morning stiffness, or dry eyes or mouth warrant a closer look for autoimmune conditions. Testing is based on your symptoms, often starting with thyroid and celiac screening.

Some autoimmune conditions are reported more often alongside endometriosis, including autoimmune thyroid disease, celiac disease, rheumatoid arthritis, psoriasis, lupus, and Sjögren’s. This doesn’t mean endometriosis causes these conditions, but overlapping immune-driven inflammation can make symptoms hard to distinguish and delay clear answers.

Symptoms that commonly warrant a closer look include persistent fatigue out of proportion to sleep, heat or cold intolerance, hair thinning or loss, ongoing digestive symptoms (especially chronic diarrhea), joint pain with swelling or morning stiffness, rashes that worsen with sun exposure, dry eyes or dry mouth, and unexplained weight change. If you have these symptoms, our team can help you decide which labs are most appropriate, often starting with thyroid testing with TSH and thyroid antibodies, celiac screening with tTG-IgA and total IgA, and targeted inflammatory or antibody testing based on your symptoms. We can also coordinate next steps as part of a comprehensive evaluation.

Where to go from here

Understand it, compare it with what you're feeling, then talk it through with us.

Step 1 · Understand

Understand the condition

Step 2 · Compare

Symptoms it can relate to

Step 3 · Speak with Us

Suspect More Than Endometriosis?

If you experience unusual fatigue, joint pain, or digestive issues along with endometriosis symptoms, it might be time to explore autoimmune testing. Our specialists can help pinpoint overlapping conditions to tailor your treatment effectively.

Questions people ask next

All general questions
  • Can endometriosis cause arthritis-like joint pain?

    Yes, endometriosis can be associated with arthritis-like joint pain in some people. Whole-body inflammation may show up as aching or stiffness, but the association does not prove causation, and persistent joint pain deserves evaluation for other conditions.

  • Is endometriosis an autoimmune disease?

    No, endometriosis is not currently classified as an autoimmune disease. It often involves chronic inflammation and changes in how the immune system responds to endometrial-like tissue outside the uterus, and some patients also have autoimmune conditions.

  • Why do people with endometriosis often have other conditions?

    The genetics, inflammation and immune-system problems involved in endometriosis may also make the body more prone to other inflammation-related or immune-associated conditions. Endometriosis can involve multiple organs, so symptoms may reflect more than one process.

Reach Out

Have a question?

Lotus Endometriosis Institute provides California-based surgical evaluation and advanced excision care for patients with suspected endometriosis, adenomyosis, complex pelvic pain, and related conditions.


Many patients contact us from outside California to learn whether traveling for in-person evaluation and possible surgery may be appropriate.

Call Us

(424) 255-1340

(805) 920-0909

Fax: (805) 935-4338

Santa Monica, CA

2121 Santa Monica Blvd, Santa Monica, CA 90404

Operating Hours

8am - 5pm
Monday - Friday

Arroyo Grande, CA

154 Traffic Way, Arroyo Grande, CA 93420