Is there a reliable blood test for endometriosis?

No—there isn’t currently an FDA-cleared blood test that can reliably diagnose (or rule out) endometriosis. Tests sometimes discussed online, such as CA-125 or newer inflammatory and microRNA-based panels, can be influenced by the menstrual cycle and many other conditions, so results are not specific enough to confirm endometriosis on their own.

In our practice, diagnosis starts with a careful review of symptoms and medical history, a focused pelvic exam when appropriate, and targeted imaging such as ultrasound or MRI to look for signs like endometriomas or deep disease. Because imaging can miss superficial disease, a normal scan does not exclude endometriosis—so if your symptoms persist, our team can help you understand what further evaluation (including whether surgery makes sense) might look like for your situation.