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Fertility

Progesterone or baby aspirin to prevent miscarriage?

The short answer

Progesterone may help some people with early pregnancy bleeding and prior miscarriages; baby aspirin is most clearly beneficial for recurrent loss linked to antiphospholipid syndrome. Routine progesterone hasn't consistently prevented miscarriage; aspirin hasn't reliably helped unexplained losses.

Progesterone support is commonly used after IVF, and it may help some people who have early pregnancy bleeding and a history of prior miscarriages. However, routinely using progesterone for everyone with a positive pregnancy test hasn’t consistently been shown to prevent miscarriage, so the decision usually depends on your specific history and how the pregnancy was conceived.

Low-dose (baby) aspirin is most clearly beneficial when recurrent loss is linked to antiphospholipid syndrome, often as part of a coordinated plan that may also include anticoagulation. For unexplained miscarriages, aspirin hasn’t reliably improved outcomes, and using it without a clear indication can add unnecessary risk or confusion. Our team can review your prior losses, labs, and fertility treatment details to recommend an approach that fits your situation. Reach out to schedule a consultation if you’d like a personalized plan.

Where to go from here

Understand it, compare it with what you're feeling, then talk it through with us.

Step 1 · Understand

Understand the condition

Step 2 · Compare

Symptoms it can relate to

Step 3 · Speak with Us

Concerned About Miscarriage?

Our specialists understand the challenges of early pregnancy and can guide you on progesterone or baby aspirin use based on your unique history. Get personalized support to improve your chances for a healthy pregnancy.

Questions people ask next

All fertility questions
  • Does endometriosis increase miscarriage risk?

    Yes, endometriosis is associated with a modest increase in miscarriage risk, particularly in the first trimester. Most pregnancies in people with endometriosis are successful, and age, pregnancy history and other uterine factors matter for individual risk.

  • What pain treatments are safe during pregnancy?

    Acetaminophen is typically the first-line pain medication during pregnancy. NSAIDs are generally avoided after 20 weeks and need obstetric guidance earlier. Non-medication options include targeted heat, gentle activity changes and pelvic floor physical therapy with a prenatal-trained clinician.

  • Are ICSI or PGT-A recommended for endometriosis?

    ICSI isn’t routinely recommended for endometriosis alone, while PGT-A can help in specific situations. ICSI decisions usually depend on semen results and past fertilization; PGT-A may help older patients or those with recurrent pregnancy loss or repeated implantation failure.

Reach Out

Have a question?

Lotus Endometriosis Institute provides California-based surgical evaluation and advanced excision care for patients with suspected endometriosis, adenomyosis, complex pelvic pain, and related conditions.


Many patients contact us from outside California to learn whether traveling for in-person evaluation and possible surgery may be appropriate.

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(424) 255-1340

(805) 920-0909

Fax: (805) 935-4338

Santa Monica, CA

2121 Santa Monica Blvd, Santa Monica, CA 90404

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Monday - Friday

Arroyo Grande, CA

154 Traffic Way, Arroyo Grande, CA 93420